The effect of chemical composition, pretreatment and microstructure of the catalyst pellet on the mass transport characteristics

Lead Research Organisation: University of Cambridge
Department Name: Chemical Engineering and Biotechnology

Abstract

The project will explore the effect of chemical composition, pretreatment and microstructure of the catalyst pellet on the mass transport characteristics relevant to catalyst preparation routes. The work will include an analysis of drying kinetics, wetting (e.g. impregnation/washcoating) and wicking. Furthermore, the project aims to investigate the use of terahertz spectroscopy and imaging as a method for determining catalyst porosity, non-destructively and quickly

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510440/1 01/10/2016 30/09/2021
1943009 Studentship EP/P510440/1 01/10/2017 30/09/2021 Mohammed Dabwan Al-Sharabi
 
Description - For the first time, terahertz pulsed imaging (TPI) was used for simultaneously investigating the liquid transport and swelling performance during the tablet disintegration of complex pharmaceutical formations. These formulations are used for patients with swallowing difficulties.
- TPI was also for the first time to study the liquid transport kinetics of catalytic materials, which revealed that, beside porosity, the surface properties of the solid catalytic material impact the transport kinetics.
- X-ray computed microtomography (µ-CT) can be used for the analysis of the microstructure properties of the inkjet-printed pharmaceuticals on porous substrates. The µ-CT results revealed the high porosity of the substrate is optimal for inkjet printing.
Exploitation Route - Help the formulation scientists in the pharmaceutical industry to design better dosage forms.
- Help in enhancing the design and the performance of heterogenous catalysts.
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology

URL https://link.springer.com/article/10.1208%2Fs12249-019-1423-y
 
Description The effect of chemical composition, pretreatment and microstructure of the catalyst pellet on the mass transport characteristics
Amount £89,640 (GBP)
Funding ID 1943009 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2021
 
Description Aalto University, School of Chemical Engineering, Department of Bioproducts and Biosystems, Aalto, Finland 
Organisation Aalto University
Country Finland 
Sector Academic/University 
PI Contribution Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Collaborator Contribution Feedback on the results of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Impact A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review.
Start Year 2017
 
Description Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Collaborator Contribution Feedback on the results of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Impact A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review.
Start Year 2017
 
Description EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, University of Strathclyde, Glasgow, UK 
Organisation EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation (CMAC)
Country United Kingdom 
Sector Public 
PI Contribution Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Collaborator Contribution Helping with the analysis of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Impact A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review.
Start Year 2017
 
Description Institute of Photonics, University of Eastern Finland, Joensuu, Finland 
Organisation University of Eastern Finland
Country Finland 
Sector Academic/University 
PI Contribution Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Collaborator Contribution Feedback on the results of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Impact A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review.
Start Year 2017
 
Description School of Pharmacy, Promis Centre, University of Eastern Finland, Kuopio, Finland 
Organisation University of Eastern Finland
Department Pharmacy Department
Country Finland 
Sector Academic/University 
PI Contribution Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Collaborator Contribution Making the tablets used for investigating the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Impact A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review.
Start Year 2017
 
Description Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, UK 
Organisation University of Strathclyde
Department Strathclyde Institute of Pharmacy & Biomedical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Collaborator Contribution Helping with the analysis of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology.
Impact A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review.
Start Year 2017