Role of CIZ1 in X chromosome inactivation

Lead Research Organisation: University of York
Department Name: Biology

Abstract

X chromosome inactivation (XCI) serves as a model for establishment and maintenance of selective transcriptional silencing throughout the genome,through the action of polycomb repressive complexes (PRC) 1 and 2. The nuclear matrix (NM) protein Cip1-interacting zinc finger protein 1 (CIZ1) plays a role in DNA replication in association with cyclins, and is linked with adult and paediatric cancers. We recently showed that CIZ1 is located at the Xi in mouse and human female cells, and that absence of CIZ1 leads to highly penetrant female-specific lympho-proliferative disorder. The data argue for a role in maintenance of X chromosome inactivation through association with the nuclear matrix. This project will investigate the mechanism by which CIZ1 functions in the maintenance of epigenetic marks as cells pass through the cell cycle, and will use a range of molecular and cellular biology techniques including high resolution and live imaging.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011151/1 30/09/2015 29/09/2023
1949445 Studentship BB/M011151/1 30/09/2017 29/06/2022 Olivia Grace Dobbs
 
Description BSCB BSDB Joint Annual Spring Meeting
Amount £490 (GBP)
Organisation British Society for Cell Biology 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 04/2018
 
Description Rotary group visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact The York Rotary Club attended for a visit to the cancer research labs at the University of York. I presented the work I was doing to small groups and did a tour of the lab, this sparked questions and discussion.
Year(s) Of Engagement Activity 2017
 
Description Second year talk to University of York students/staff 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 15 minute presentation regarding my work so far in my PhD to both students and staff of the University of York, Biology Department. This was a chance for me to show my data and to also discuss future ideas with my peers.
Year(s) Of Engagement Activity 2019