C-H activation: design and development of novel catalytic systems for synthetic chemistry

Lead Research Organisation: University of Manchester
Department Name: Chemistry

Abstract

Catalytic C-H functionalisation aims at developing new tools enabling the transformation of any C-H bond in an organic molecule into the desired functionality. Once chemists have developed a whole set of tools (catalysts) for C-H functionalisation, the fast and efficient synthesis of any molecule will be a simple task. In this project we will study how ruthenium salts can be used as catalysts to carry out C-H functionalisation and how to control their reactivity. What are the key elements in ruthenium catalysts that allow modifying the site of C-H functionalisation? What changes can be made to accelerate the catalytic activity of these ruthenium salts? In order to answer these questions we will apply state of the art mechanistic investigations, including kinetics, stoichiometric studies and computational studies. Subsequently, we will combine all lessons learned into the design of new ruthenium catalysts and their application to the development of new synthetic transformations for the efficient preparation of important structural motifs in pharmaceutical, agrochemical and organic electronic materials.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509565/1 01/10/2016 30/09/2021
1952889 Studentship EP/N509565/1 01/09/2017 30/09/2021 Matthew Wheatley
 
Description We have obtained new reactivity with a class of C-H activation catalysts discovered in our lab, allowing for the synthesis of molecules that would otherwise be much more challenging
Exploitation Route This research may hopefully find applications in the discovery sector of the pharmaceutical and/or agrochemical industries. However, if this is to happen, it will be a long time away
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology