Copper catalysed formation of C-X bonds

Lead Research Organisation: Imperial College London
Department Name: Dept of Chemistry

Abstract

Copper-catalysed Ullmann condensation reactions represent an under-developed alternative to the use of Buchwald-Hartwig palladium chemistry for the formation of carbon-heteroatom bonds. However, the systems suffer from poorer efficiency and substrate scope. In the last decade a major innovation in the Ullmann condensation is the use of bidentate ligands which are believed to stabilise on-cycle catalytic species, facilitating oxidative addition, and preventing over-coordination of the nucleophile. This has led to improved reaction conditions and reduced catalytic loading; though copper systems still lag behind their palladium counterpart.
This project will discover new copper-ligand systems exploiting N-heterocyclic carbenes (NHCs), with a second coordinating group. A comprehensive investigation covering new ligand designs and reaction conditions will be carried out in order to develop optimised systems for accessing valuable motifs in drug discovery.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509486/1 01/10/2016 30/09/2021
1955223 Studentship EP/N509486/1 01/10/2017 14/08/2018 Rebecca Lane