Electromagnetic spectrum on biomarkers of skin function and intervention of such effects

Lead Research Organisation: Newcastle University
Department Name: Institute of Cellular Medicine

Abstract

Sunscreens and related compounds are known to slow down the process of skin ageing caused by exposure to ultraviolet radiation (UVR) in sunlight. The sunscreens and related compounds also contain actives which contribute the skin protection and anti-ageing of the products. The objectives are to determine the biochemical effects of aspects of the electromagnetic spectrum on biomarkers of skin function and its commercial application towards the modulation and intervention of such effects

This science together with the direct links with Croda and its benefit to the UK market and beyond fits very well with the BBSRC vision to lead world-class 21st century bioscience, promoting innovation in the bioeconomy and realising benefits for society within and beyond the UK. The project clearly complies with the BBSRC vision statement of "Staying healthier for longer as lifespans increase and society ages"; the BBSRC strategic research priority of "bioscience for health" and the BBSRC enabling theme of "partnerships".

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/R505857/1 01/10/2017 30/09/2021
1959726 Studentship BB/R505857/1 01/10/2017 30/09/2021 Catherine Anne Bonn
 
Description It is known that in ultraviolet light from the sun damages human skin. Data from this award shows that in human cells grown in vitro, markers of damage are increased when cells are exposed to ultraviolet, visible light and infrared light together compared to just ultraviolet alone. Specifically, mitochondrial and nuclear DNA damage was increased, as was reactive oxygen species concentration.

This effect was seen in fibroblast cells from the human dermis but not keratinocyte cells from the human epidermis. These cells types are thus differently susceptible to damage from light of different wavelegths.
Exploitation Route The findings may inform the development of sunscreens which optimally protect skin from damage from sunlight.
Sectors Manufacturing, including Industrial Biotechology

 
Description Contributing data for a product data sheet for a Croda sunscreen ingredient. The data has contributed to the development and understanding of the products properties, so Croda can provide this information to customers. The imporoved knowledge of the properties of the product could influence its attractiveness to sunscreen manufacturers who may include it in their formulations for marketable benefits.
First Year Of Impact 2019
Sector Manufacturing, including Industrial Biotechology
Impact Types Economic

 
Description Croda PhD sponsorhsip 
Organisation Croda Europe Ltd
Country United Kingdom 
Sector Private 
PI Contribution Data from project
Collaborator Contribution Some sunscreen materials for testing.
Impact DOI: 10.1096/fj.201902351RR (though other projects have also contributed to this publication).
Start Year 2017
 
Description "Power Hour" - a talk with customers of Croda about their technologies and this research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A presentation by Mark Birch-Machin hosted by Croda for Croda customers to demonstrate and discuss their products, including findings from this award.
Year(s) Of Engagement Activity 2020
URL https://event.on24.com/eventRegistration/EventLobbyServlet?target=reg20.jsp&partnerref=website&event...
 
Description Presentation to Croda 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact A presentation was made alongside other PhD students also part funded by Croda to members of Croda management teams. The intention was to demonstrate our knowledge of business needs and research areas that align with the company's values and strategy.
Year(s) Of Engagement Activity 2020