A two photon imaging platform for characterising memory circuit dynamics and response to therapeutic strategies in neurodegenerative disease

Lead Research Organisation: Imperial College London
Department Name: Dept of Bioengineering

Abstract

Neurodegenerative disorders such as Alzheimer's Disease are a growing problem for society. While there are a number of disease models, based on amyloid and tau protein pathologies, and even several promising treatment approaches, there have been difficulties in transferring apparent success in animal models into successful human clinical trials. One key issue is that the effect of neurodegenerative disease on memory circuit dynamics during a spatial memory task is not well understood, nor is the effect of therapeutic strategies on information flow in hippocampal-cortical circuits. In this project we will develop a platform for characterising such information flow, combining a two photon microscope system for deep tissue imaging with a platform for mouse behaviour. A number of technological challenges will have to be overcome in the project, ranging from synchronizing multimodal measurements (optical, electrophysiological, behavioural) together, to the development of a robust signal processing and data analysis pipeline.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R512540/1 01/10/2017 30/09/2021
1975558 Studentship EP/R512540/1 02/10/2017 31/10/2021 Seigfred Valderama Prado