Stochastic Treatments of Mitochondrial Genetics
Lead Research Organisation:
Imperial College London
Department Name: Dept of Mathematics
Abstract
Mitochondrial mutations are responsible for diseases in development and of later life. This project investigates how levels of mutation might fluctuate in tissues and how these fluctuations could feasibly controlled. We are taking mathematical models which have been described for single cells and carefully analysing some of their statistical properties to identify when mutations might reach high levels inside cells. We are also examining what might happen if different cells are coupled together. This work would be classified as applied probability/statistics or mathematical biology. This work will be joint with Cambridge Clinical Neuroscience.
People |
ORCID iD |
Nick Jones (Primary Supervisor) | |
Ferdinando Insalata (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N509486/1 | 01/10/2016 | 30/09/2021 | |||
2032993 | Studentship | EP/N509486/1 | 01/10/2017 | 31/03/2021 | Ferdinando Insalata |
Description | We have found that ageing in skeletal muscle fibres can take place through a novel evolutionary mechanism. |
Exploitation Route | Our model and the resulting understanding of muscle ageing can pave the way for therapeutic interventions. |
Sectors | Healthcare |
URL | https://scholar.google.com/scholar?cluster=4234389864288178971&hl=en&oi=scholarr |
Description | Collaboration with the Mitochondrial Biology Unit, University of Cambridge |
Organisation | University of Cambridge |
Department | Cambridge Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provided mathematical models to describe previously unexplained phenomena in mitochondrial biology. Provided predictions for model of mitochondrial DNA control by the nucleus. |
Collaborator Contribution | Provided more in-depth knowledge of mitochondrial biology, started experiments to validate our model |
Impact | No outcome yet |
Start Year | 2017 |