Antibacterial resistance development in agriculture and transmission on surfaces.

Lead Research Organisation: University of Birmingham
Department Name: Institute of Microbiology and Infection

Abstract

The increase in antimicrobial resistance (AMR) is a recognised global problem. Current forecasts project that by 2050, it will have led to 10 million preventable deaths, and cost the global economy in excess of £66 trillion. Research and development across different sectors will be key in tackling this problem. This project will investigate the potential for using antibacterial surfaces in agricultural settings to prevent the spread of infection. The novel technology being studied consists of antibacterial peptides coupled chemically to surfaces, which renders them much less susceptible to bacterial colonisation, and hence helps break the chain of transmission which is a key factor in the spread of AMR. In both lab-based and "real world" studies, such surfaces have proven highly effective at decreasing the spread of bacteria. The current project will seek to explore this approach in agricultural settings, and will also study the mechanisms of killing and examine whether or not the emergence of resistance is likely to be a problem. It is generally recognised that overuse of antibiotics in agriculture is a major contributor to the evolution and spread of AMR, and even though legislation is beginning to restrict some of this overuse, there are still major concerns about misuse and about high levels of antibiotics in farm run-off selecting for resistant organisms.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
2098537 Studentship BB/M01116X/1 01/10/2018 30/09/2022 Manpreet Kaur