Understanding the novel aspects of PERK signalling and
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Neurosciences
Abstract
1. To further characterise the novel PERK non-canonical signalling protein partners which interact with PERK via its cytoplasmic domain.
2. To develop cell-based assays which can monitor these interactions
3. To use these assays to screen compound libraries to identify compounds that specifically impact the PERK non-canonical signalling pathway and to investigate their potential neuroprotective capabilities in rodent models of neurodegeneration.
2. To develop cell-based assays which can monitor these interactions
3. To use these assays to screen compound libraries to identify compounds that specifically impact the PERK non-canonical signalling pathway and to investigate their potential neuroprotective capabilities in rodent models of neurodegeneration.