Synthesis and mode of action studies to elucidate novel trypanocidal agaents

Lead Research Organisation: University of St Andrews
Department Name: Chemistry

Abstract

The student will be undertaking various types of chemical synthesis of various natural product motifs, including making a range of lipid-like molecules to explore structure activity relationships against specific enzymes, as well as protozoan parasites that cause neglected tropical disease.
The student will be fully trained at a Cat 3 level to undertake parasite and mammalian cell culture and biochemical manipulations. This will allow them to undertake EC50 value determinations and biochemical phenotyping. The student will subsequently synthesise and utilize novel affinity probes of their best hits, to ensure "on-target" and mode of action studies.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R513337/1 01/10/2018 30/09/2023
2259647 Studentship EP/R513337/1 01/09/2019 28/02/2023 Rachel Griffiths Humann