Three-Dimensional Tissue-Like Sensing Arrays for Cerebral Brain Organoids

Lead Research Organisation: University of Cambridge
Department Name: Chemical Engineering and Biotechnology

Abstract

Cerebral organoids sit at the interface between in vivo and in vitro, with complex cell composition, maturation and tissue architecture mimicking early brain development. This interdisciplinary project aims to facilitate the study of cerebral organoids through the development of a novel three-dimensional electrode sensing array. The array will monitor cellular activity through electrophysiological recording, providing insight into the neural network connections guiding organoid development. Further iterations of the original design will look to host chemical stimulation protocols to specifically control cellular functions. It is anticipated that the technologies developed in this project will find applications in other three-dimensional organoids and in vivo animal models.

Research Areas: Microelectronic device technology, Sensors and instrumentation, Clinical technologies (excluding imaging)

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S023046/1 30/09/2019 30/03/2028
2394429 Studentship EP/S023046/1 30/09/2020 29/09/2024 Nuzli Bethany Karam