The role of NKT cells and lipid stimuli in the development of allergic sensitisation

Lead Research Organisation: University of Nottingham
Department Name: School of Life Sciences

Abstract

This project aims to investigate the influence of lipids from an allergen source to shift towards a Th2 response of allergic sensitisation.

Techniques will be developed to isolate and characterise natural killer T (NKT) cells from human blood samples and then co-culture iNKT cells with lipid and/or protein-loaded dendritic cells. The subsequent cytokine response will be measured using assays to determine whether a Th2 response has been produced. These techniques will be applied to allergic and non-allergic blood samples to characterise the lipid-activation profiles of NKT cells in each group.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/S506928/1 01/10/2018 30/09/2022
2397745 Studentship BB/S506928/1 01/10/2018 30/09/2022 Georgina Hopkins