Smart biomaterial composites with hierarchical architecture for ligament repair and regeneration

Lead Research Organisation: University of Manchester
Department Name: Engineering and Physical Sciences

Abstract

The project involves clinical input and a real opportunity to map age related tissue profiling and differentiation via examining ligament tissues from patients that goes under ACL reconstruction surgery.
We will address the influence of the hierarchical multi-scale physical construct of the ligament tissue on the mechanical properties.
Can we use the mimic such complex hierarchical order in of the collagen using simple polysaccharides such as cellulose and chitin in 2D and 3D?
How do multiscale ordered fibrillar structures need to be processed and optimized to give optimum mechanical properties?
Is it possible to bioprint 3D cellular constructs with multiscale (macro-micro-nano) architectures and how does that improve the long-term biomechanical performance of the graft?

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S022201/1 01/04/2019 30/09/2027
2426660 Studentship EP/S022201/1 01/10/2020 30/09/2024 Matthew Graham