Determine the role RAMPs perform in modulating human cardiomyocytes function and regeneration
Lead Research Organisation:
University of Cambridge
Department Name: Pharmacology
Abstract
Determine the role RAMPs perform in modulating human cardiomyocytes function
and regeneration
and regeneration
People |
ORCID iD |
| Graham Ladds (Primary Supervisor) | |
| Theo Redfern-Nichols (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/V509334/1 | 01/10/2020 | 30/09/2024 | |||
| 2471656 | Studentship | BB/V509334/1 | 01/10/2020 | 30/09/2024 | Theo Redfern-Nichols |
| Description | So far, through the first publication, an unexpected finding has been discovered about the Calcitonin Receptor-like Receptor (CLR). This receptor is present in human cardiomyocytes and interacts with RAMPs (modulatory proteins mentioned in the award title). Hence, findings pertaining to this receptor are relevant to the award. This phenomenon is that the receptor is 'internalised' (taken inside cells) in an atypical way, compared to other receptors of its type. |
| Exploitation Route | Anyone wishing to look at CLR internalisation knows how to add GRKs to reduce membrane expression. Others may infer that there is a reduced level of CLR membrane expression, if there is expression of GRKs (GPCR Kinases). |
| Sectors | Pharmaceuticals and Medical Biotechnology |