Decarboxylative fluorination and trifluoromethylation of benzoic acids

Lead Research Organisation: University of Manchester
Department Name: Chemistry

Abstract

Objective:
This project will investigate the development of novel catalytic methods capable of transforming benzoic acids and heteroaromatic carboxylic acids into the corresponding decarboxofluorinated products.
Approach:
The student will examine the use of transition metal catalysts to mediate the 'activation' of the carboxyl C-C bond, resulting in a decarboxylative process. Subsequently, this process shall be coupled with a C-F bond forming step.
Novelty:
There are no broad methods available to carry out this transformation. Benzoic acids are extremely readily available, and fluorinated motifs are common in drugs and other biologically active molecules.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/T517823/1 30/09/2020 29/09/2025
2481226 Studentship EP/T517823/1 20/09/2020 17/02/2021 Eleanor Bowen