6EF63C3A-635D-49E6-9DF0-731045FCE31DA systems approach to understanding metabolic switching in Streptomyces coelicolorResearch GrantBB/F003498/12512EF1C-401B-4222-9869-A770D4C5FAC7BBSRCINCOME_ACTUAL1251542A9A2934A-8554-4C71-8504-8F994C54D913Software Tools and Algorithms for Biological Systemsd6ee6c77e37be1e5ac51df75a7f11dbeArabnia, Hamid R.; Tran, Quoc-Nam Professor2011-01-01978-1-4419-7045-9Streptomyces coelicolor, the model species of the genus Streptomyces, presents a complex life cycle of successive morphological and biochemical changes involving the formation of substrate and aerial mycelium, sporulation and the production of antibiotics. The switch from primary to secondary metabolism can be triggered by nutrient starvation and is of particular interest as some of the secondary metabolites produced by related Streptomycetes are commercially relevant. To understand these events3-15Book Chapteri-4231217870.70410163bd0928e