Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Engagement Activities
the cilium in chondrocyte mechanotransduction
Impact Summary
working in the field of bacterial flagella biogenesis.
Collaboration
Analysis of primary cilia in human cells
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Collaboration
Functional Conservation in Ciliary Trafficking
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Engagement Activities
the University of Southampton
Engagement Activities
Talk
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
PCD male fertility assessment
Engagement Activities
Mucociliary Interactions
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
Collaboration with molecular basis of disease and therapeutics
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Engagement Activities
flagella - Talk
Key Findings
cilia to be resorbed and identified the pathway responsible
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
UK Cilia Network
Collaboration
Developing calcium sensors in green algae
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Analysis of cilia development and patterning