A platform for the generation of natural product-based non-ribosomal peptide libraries
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
A platform for the generation of natural product-based non-ribosomal peptide libraries
description: Non-ribosomal peptides are an interesting class of natural products, with several members showing impressive bioactivity against a variety of diseases. As such they have been extensively employed as therapeutic agents. A platform for the generation and screening of compound libraries based on these structures would be extremely valuable in drug discovery. Here, we will develop a method for the generation of randomised libraries of natural-product-like compounds. These compounds will be assayed for inhibition of a given protein-protein interaction.
description: Non-ribosomal peptides are an interesting class of natural products, with several members showing impressive bioactivity against a variety of diseases. As such they have been extensively employed as therapeutic agents. A platform for the generation and screening of compound libraries based on these structures would be extremely valuable in drug discovery. Here, we will develop a method for the generation of randomised libraries of natural-product-like compounds. These compounds will be assayed for inhibition of a given protein-protein interaction.
Organisations
People |
ORCID iD |
| Cyrielle Doigneaux (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509747/1 | 30/09/2016 | 29/09/2021 | |||
| 1795526 | Studentship | EP/N509747/1 | 30/09/2016 | 29/09/2019 | Cyrielle Doigneaux |