Proton-sensing GPCR signalling in inflammation
Lead Research Organisation:
University of Cambridge
Department Name: Pharmacology
Abstract
Theme: Bioscience for Health
My project involves the use of cell lines, primary cultured sensory neurones and mice to assess the contributions of proton-sensing G protein-couple receptors in inflammation and the associated pain.
My project involves the use of cell lines, primary cultured sensory neurones and mice to assess the contributions of proton-sensing G protein-couple receptors in inflammation and the associated pain.
People |
ORCID iD |
| Luke Pattison (Student) |
Publications
Chakrabarti S
(2018)
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
in Neuropharmacology
Lu VB
(2019)
Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
in Nature communications
Pattison LA
(2019)
Evolution of acid nociception: ion channels and receptors for detecting acid.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Callejo G
(2020)
In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.
in Biochemical pharmacology
Bohic M
(2023)
Mapping the neuroethological signatures of pain, analgesia, and recovery in mice.
in Neuron
Pattison L
(2021)
Proton-sensing G protein-coupled receptor signalling in inflammation
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011194/1 | 30/09/2015 | 31/03/2024 | |||
| 1943916 | Studentship | BB/M011194/1 | 30/09/2017 | 30/12/2021 | Luke Pattison |
| NE/W503204/1 | 31/03/2021 | 30/03/2022 | |||
| 1943916 | Studentship | NE/W503204/1 | 30/09/2017 | 30/12/2021 | Luke Pattison |