Maximising patient benefit: Leeds’ Interdisciplinary approach to translation
Lead Research Organisation:
University of Leeds
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
People |
ORCID iD |
| Paul Stewart (Principal Investigator) |
Publications
Hardy LJ
(2023)
Glycated albumin modulates the contact system with implications for the kallikrein-kinin and intrinsic coagulation systems.
in Journal of thrombosis and haemostasis : JTH
Shawer H
(2021)
ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling.
in Frontiers in cell and developmental biology
Bentley R
(2021)
Drugs in phase I and II clinical development for the prevention of stroke in patients with atrial fibrillation.
in Expert opinion on investigational drugs
Charalambous A
(2021)
Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, combretastatin A4.
in Nanomedicine : nanotechnology, biology, and medicine
Bao P
(2021)
Production of giant unilamellar vesicles and encapsulation of lyotropic nematic liquid crystals.
in Soft matter
Batchelor D
(2021)
Nanobubbles for therapeutic delivery: Production, stability and current prospects
in Current Opinion in Colloid & Interface Science
Kearney K
(2021)
Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI
in Proceedings of the National Academy of Sciences
Kirkby CJ
(2021)
Developing a Raman spectroscopy-based tool to stratify patient response to pre-operative radiotherapy in rectal cancer.
in The Analyst
Bourn M
(2020)
High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures
in Journal of Controlled Release
Ye S
(2020)
One-Step Preparation of Biocompatible Gold Nanoplates with Controlled Thickness and Adjustable Optical Properties for Plasmon-Based Applications
in Advanced Functional Materials
| Description | Flight |
| Amount | £8,484 (GBP) |
| Organisation | The ITP Support Association |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2021 |
| Description | HyperTerahertz - High precision terahertz spectroscopy and microscopy |
| Amount | £6,517,861 (GBP) |
| Funding ID | EP/P021859/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 05/2022 |
| Description | Optimising the affinity and format of a lead candidate biotherapeutic for the treatment of immune thrombocytopenia |
| Amount | £28,576 (GBP) |
| Funding ID | M866 |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 08/2022 |
| Description | The impact of Fc gamma receptor polymorphisms on treatment response in adult patients with primary immune thrombocytopenia |
| Amount | £25,992 (GBP) |
| Organisation | British Medical Association (BMA) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 09/2021 |