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Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it

Lead Research Organisation: University of Manchester
Department Name: Chemistry

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Laubscher GJ (2021) TEG®, Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy. in Journal of clinical medicine

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Kruger A (2022) Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system. in Cardiovascular diabetology

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Koperdanova M (2015) Interpreting raised serum ferritin levels. in BMJ (Clinical research ed.)

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Kenny L (2018) Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father† in Frontiers in Medicine

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Kenny L (2017) Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father 1

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Kell DB (2015) The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen). in Integrative biology : quantitative biosciences from nano to macro

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Kell DB (2022) A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. in The Biochemical journal

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Kell DB (2017) Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting. in Progress in biophysics and molecular biology

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Kell DB (2014) Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. in Metallomics : integrated biometal science

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Kell DB (2022) The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications. in The Biochemical journal

 
Description Discovery of amyloid formation by clotting blood. Absolutely humungous discovery.

Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications.
Exploitation Route Novel diagnostics.
Sectors Digital/Communication/Information Technologies (including Software)

Education

Healthcare

Pharmaceuticals and Medical Biotechnology
 
Description Stellenbosch 
Organisation University of Stellenbosch
Country South Africa 
Sector Academic/University 
PI Contribution Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement.
Collaborator Contribution Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool.
Impact See publications.
Start Year 2017