The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
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Organisations
Publications
Hong Sung You
(2009)
Functionalization of single walled carbon nanotubes with carbohydrates
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Gamblin DP
(2009)
Glycoprotein synthesis: an update.
in Chemical reviews
French AC
(2009)
High-purity discrete PEG-oligomer crystals allow structural insight.
in Angewandte Chemie (International ed. in English)
Lin YA
(2010)
Olefin cross-metathesis on proteins: investigation of allylic chalcogen effects and guiding principles in metathesis partner selection.
in Journal of the American Chemical Society
Kemper S
(2010)
Group epitope mapping considering relaxation of the ligand (GEM-CRL): including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Scanlan EM
(2010)
Synthesis and solution-phase conformation of the RG-I fragment of the plant polysaccharide pectin reveals a modification-modulated assembly mechanism.
in Journal of the American Chemical Society
Patel MK
(2010)
Flow chemistry kinetic studies reveal reaction conditions for ready access to unsymmetrical trehalose analogues.
in Organic & biomolecular chemistry
Hong SY
(2010)
Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging.
in Nature materials
Wyszynski FJ
(2010)
Inverted regioselectivity of C-H amination: Unexpected oxidation at beta- rather than gamma-C-H.
in Organic & biomolecular chemistry
| Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
| Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
| Sectors | Education Pharmaceuticals and Medical Biotechnology |
| URL | http://users.ox.ac.uk/~dplb0149/index.html |
| Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
| First Year Of Impact | 2009 |
| Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
| Impact Types | Cultural Societal Economic Policy & public services |
| Company Name | GlycoForm |
| Description | |
| Year Established | 2002 |
| Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |