Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Philip Alan Gale (Principal Investigator) |
Publications
Haynes CJ
(2013)
Small neutral molecular carriers for selective carboxylate transport.
in Chemical communications (Cambridge, England)
Cranwell PB
(2013)
Anion recognition and transport properties of sulfamide-, phosphoric triamide- and thiophosphoric triamide-based receptors.
in Chemical communications (Cambridge, England)
Moore S
(2013)
Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas
in Chem. Sci.
Busschaert N
(2013)
Towards predictable transmembrane transport: QSAR analysis of anion binding and transport
in Chemical Science
Ko SK
(2014)
Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells.
in Nature chemistry
Karagiannidis LE
(2014)
Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas.
in Chemical communications (Cambridge, England)
Haynes CJ
(2014)
Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding.
in Organic & biomolecular chemistry
Davis JT
(2014)
Ion transport: Tipping a cell's ionic balance.
in Nature chemistry
Busschaert N
(2014)
Thiosquaramides: pH switchable anion transporters
in Chem. Sci.
Gale PA
(2014)
Anion receptor chemistry: highlights from 2011 and 2012.
in Chemical Society reviews
Busschaert N
(2014)
Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport
in Chemical Science
Valkenier H
(2014)
Lipophilic balance - a new design principle for transmembrane anion carriers
in Chemical Science
Merckx T
(2015)
Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines.
in Organic & biomolecular chemistry
Elmes RB
(2015)
pH switchable anion transport by an oxothiosquaramide.
in Chemical communications (Cambridge, England)
Edwards S
(2015)
High-Affinity Anion Binding by Steroidal Squaramide Receptors
in Angewandte Chemie
Busschaert N
(2015)
ChemInform Abstract: Applications of Supramolecular Anion Recognition
in ChemInform
Berry SN
(2015)
Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism.
in Organic & biomolecular chemistry
Busschaert N
(2015)
Applications of Supramolecular Anion Recognition
in Chemical Reviews
Kadam SA
(2015)
Towards the discrimination of carboxylates by hydrogen-bond donor anion receptors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Edwards S
(2015)
High-Affinity Anion Binding by Steroidal Squaramide Receptors
in Angewandte Chemie International Edition
Wu X
(2015)
Dynamic covalent transport of amino acids across lipid bilayers.
in Journal of the American Chemical Society
Berry SN
(2016)
Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells.
in Chemical science
Gale P
(2016)
Anion Receptor Chemistry
in Chem
Knight NJ
(2016)
QSAR analysis of substituent effects on tambjamine anion transporters.
in Chemical science
| Description | We prepared new small molecules designed to transport anions across lipid bilayer membranes. Along the way, we discovered new fundamental physical organic chemistry regarding the transport of anions and also on the mechanisms by which anion transporters can facilitate the transport of protons across lipid bilayers. We found that proton transport can be facilitated by anion transporters transporting fatty acid head groups through the bilayer. This is an important finding and points the way forward to the design of selective transporters that can facilitate chloride transport (but not protons) that may be of use in the treatment of cystic fibrosis. We have also demonstrated that anion transporters could be used alongside cystic fibrosis treatments to enhance anion transport through epithelial cell membranes. |
| Exploitation Route | The findings from this proposal show how to selectively transport anions across lipid bilayers and may be used as the basis for new generations of compounds for the treatment of diseases such as cystic fibrosis and cancer. |
| Sectors | Chemicals Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Australian Research Council Discovery Grant 2018 |
| Amount | $524,708 (AUD) |
| Funding ID | DP180100612 |
| Organisation | Australian Research Council |
| Sector | Public |
| Country | Australia |
| Start | 01/2018 |
| End | 12/2020 |