📣 Help Shape the Future of UKRI's Gateway to Research (GtR)

We're improving UKRI's Gateway to Research and are seeking your input! If you would be interested in being interviewed about the improvements we're making and to have your say about how we can make GtR more user-friendly, impactful, and effective for the Research and Innovation community, please email gateway@ukri.org.

Exploring the origins and activation dynamics of the endometriosis-associated macrophage in a novel mouse model

Lead Research Organisation: University of Edinburgh
Department Name: MRC Centre for Reproductive Health

Abstract

Endometriosis is a chronic inflammatory condition that affects 1 in 10 women of reproductive age. It is associated with debilitating pelvic pain and infertility and has a huge adverse impact on health-related quality of life. Current therapies are limited to surgery or hormonal suppression. Women want new alternatives to current treatment options.

People

ORCID iD
Chloe Hogg (Student)

Publications

10 25 50
publication icon
Horne AW (2019) Repurposing dichloroacetate for the treatment of women with endometriosis. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Hogg C (2020) Endometriosis-Associated Macrophages: Origin, Phenotype, and Function. in Frontiers in endocrinology

publication icon
Hogg C (2020) Macrophages inhibit and enhance endometriosis depending on their origin

publication icon
Hogg C (2021) Macrophages inhibit and enhance endometriosis depending on their origin. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Forster R (2019) Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

publication icon
Chang CY (2022) Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications. in Biomedicines

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/P502030/1 30/09/2016 29/09/2022
1789503 Studentship MR/P502030/1 31/08/2016 30/08/2019 Chloe Hogg
 
Description Barbour Watson Trust- awarded to Chloe Hogg PhD student
Amount £2,000 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 12/2018
 
Description Research Grant
Amount £698,969 (GBP)
Funding ID MR/S002456/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 12/2021
 
Description Travel grant
Amount £800 (GBP)
Organisation Society for Reproduction and Fertility 
Sector Charity/Non Profit
Country Global
Start 06/2018 
End 08/2019
 
Description Secretary of the Little France Postgraduate Society 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact On the postgraduate committee I organised a plethora of events from social events to career development workshops. We welcomed new students onto the campus and aided the sometimes difficult transition into postgraduate life. We also set up a SolidariTEA event where postgraduates seeking help could come and get support in a confidential environment, with the aim to promote good mental health and communication between like-minded students facing similar issues.
Year(s) Of Engagement Activity 2017,2018,2019