UoSheffield Confidence in Concept 2013
Lead Research Organisation:
University of Sheffield
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
Publications
Williams R
(2014)
Computational Models of the NF-KB Signalling Pathway
in Computation
Williams R
(2015)
The rise in computational systems biology approaches for understanding NF-?B signaling dynamics
in Science Signaling
Paredes B
(2015)
Cryogenic Gaseous Photomultiplier for position reconstruction of liquid argon scintillation light
in Journal of Instrumentation
Williams R
(2016)
Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems
in PLOS ONE
Misra J
(2016)
Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function.
in Stem cells (Dayton, Ohio)
AlMalki FA
(2016)
Direct observation of DNA threading in flap endonuclease complexes.
in Nature structural & molecular biology
Roman S
(2016)
Development of an implantable synthetic membrane for the treatment of preterm premature rupture of fetal membranes.
in Journal of biomaterials applications
Bergmann K
(2018)
Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish.
in Journal of developmental biology
Roman S
(2018)
Visualisation of the insertion of a membrane for the treatment of preterm rupture of fetal membranes using a synthetic model of a pregnant uterus.
in Journal of biomaterials applications
Wong SQ
(2018)
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
in Journal of neuroscience methods
Paggiosi M
(2021)
Are non-fracture vertebral deformities more prevalent in patients with osteoporotic vertebral fractures?
in Bone Reports
Morris PD
(2021)
A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease.
in Cardiovascular research
Solanki R
(2021)
The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.
in Scientific reports
Chen Z
(2022)
Zoledronate Extends Health Span and Survival via the Mevalonate Pathway in a FOXO-dependent Manner.
in The journals of gerontology. Series A, Biological sciences and medical sciences
| Description | Clinical Lectureship |
| Amount | £200,000 (GBP) |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 09/2019 |
| Description | Clinical Research Fellowship |
| Amount | £1,760,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 08/2022 |
| Description | Developing new molecules to treat antimicrobial resistant gonorrhoea |
| Amount | £471,975 (GBP) |
| Funding ID | 971625 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2020 |
| Description | Development of inhibitors of bacterial flap endonucleases for use as antimicrobial agents |
| Amount | £140,000 (GBP) |
| Funding ID | 132660 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2018 |
| Title | VOLUMETRIC BLOOD FLOW |
| Description | A computer-implemented method of determining data indicating volumetric flow rate within an artery. The method comprises receiving data indicating a proximal pressure measurement relative to a direction of blood flow; receiving data indicating a distal pressure measurement relative to the direction of blood flow; wherein the proximal pressure measurement and the distal pressure measurement are obtained using at least one pressure transducer; receiving geometric model data representing the artery, wherein the geometric model data is generated based upon image data indicative of the artery; and computing a volumetric flow rate with in the artery, wherein computing comprises performing a numerical simulation of blood flow through the artery based upon the geometric model data, the data indicating a proximal pressure measurement and the data indicating a distal pressure measurement. |
| IP Reference | WO2020035662 |
| Protection | Patent granted |
| Year Protection Granted | 2020 |
| Licensed | Commercial In Confidence |
| Impact | Commercial In Confidence |
| Company Name | DeFENition |
| Description | DeFENition is developing a new class of antibiotics focussed on a flap endonucleases (FENs); a group of enzymes that are vital for the growth of bacterial cells. |
| Year Established | 2016 |
| Impact | Research and experimental development on biotechnology https://gtr.ukri.org/organisation/F2281468-1587-4E48-A868-B2B0209D0798 |
| Website | http://www.toptechnology.co.uk |