Stem cell-derived exosomes for regenerative medicine
Lead Participant:
RENEURON LIMITED
Abstract
ReNeuron is a leading UK regenerative medicine company currently conducting clinical trials with a novel
human neural stem cell (hNSC) product for the treatment of stroke and limb ischaemia. These stem cells also
produce small parcels of biologic material called exosomes. CTX-derived exosomes have been found to have
functional properties in laboratory models of cancer, particularly glioblastomas. It may therefore be feasible to
use the exosomes as an alternative class of regenerative medicine that has a long shelf-life and application to a
wide range of diseases. In this project, we will tackle how to purify exosomes in large enough quantities cost-
effectively at scale and then complete preclinical studies for a clinical trial application in glioblastoma. If
successful, our project will benefit patients with the target disease as well as the UK regenerative medicine
industry.
human neural stem cell (hNSC) product for the treatment of stroke and limb ischaemia. These stem cells also
produce small parcels of biologic material called exosomes. CTX-derived exosomes have been found to have
functional properties in laboratory models of cancer, particularly glioblastomas. It may therefore be feasible to
use the exosomes as an alternative class of regenerative medicine that has a long shelf-life and application to a
wide range of diseases. In this project, we will tackle how to purify exosomes in large enough quantities cost-
effectively at scale and then complete preclinical studies for a clinical trial application in glioblastoma. If
successful, our project will benefit patients with the target disease as well as the UK regenerative medicine
industry.
Lead Participant | Project Cost | Grant Offer |
---|---|---|
RENEURON LIMITED | £1,315,613 | £ 920,929 |
  | ||
Participant |
||
UNIVERSITY COLLEGE LONDON | ||
UNIVERSITY COLLEGE LONDON | £443,160 | £ 443,160 |
CELL THERAPY CATAPULT LIMITED | £740,151 | £ 740,151 |
THE NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST | ||
RENEURON GROUP PLC |
People |
ORCID iD |
Rikki Arnold (Project Manager) |