Design, Transfer and Qualification of a Commercially-Scalable Process for Viral Vectors
Lead Participant:
AUTOLUS LIMITED
Abstract
"Advanced Therapies have come of age. The spectacular clinical results demonstrated by novel gene-engineered T-cell therapies, with subsequent regulatory approvals in the US, have confirmed the commercial reality of a new class of therapeutics that offer real hope to patients who are bereft of effective treatment options. But behind this hope lies a deep concern that high cost-of-goods and problematical scalability will severely limit patient access to these therapies.
A critical component of these therapies is a recombinant viral vector capable of effectively transducing the T-cells and enabling the expression of novel anti-tumour receptors. Unfortunately, the current technologies to manufacture these vectors at commercial scales are not fit for purpose. This project will combine leading academic expertise and the commercial imperative of a UK Biotech company to create innovative and scalable viral vector processes that will facilitate patient access to Advanced Therapies."
A critical component of these therapies is a recombinant viral vector capable of effectively transducing the T-cells and enabling the expression of novel anti-tumour receptors. Unfortunately, the current technologies to manufacture these vectors at commercial scales are not fit for purpose. This project will combine leading academic expertise and the commercial imperative of a UK Biotech company to create innovative and scalable viral vector processes that will facilitate patient access to Advanced Therapies."
Lead Participant | Project Cost | Grant Offer |
---|---|---|
AUTOLUS LIMITED | £1,231,489 | £ 738,893 |
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Participant |
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UNIVERSITY COLLEGE LONDON | ||
UNIVERSITY COLLEGE LONDON | £486,954 | £ 486,954 |
People |
ORCID iD |
Helen Delahaye (Project Manager) |