Developing novel tools to probe the function of GPR37 within the CNS
Lead Research Organisation:
University of Sussex
Department Name: Sch of Life Sciences
Abstract
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People |
ORCID iD |
| John Atack (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M01715X/1 | 01/11/2015 | 31/08/2018 | |||
| 1661841 | Studentship | BB/M01715X/1 | 01/11/2015 | 30/08/2018 |
| Description | A cellular model incorporating the drug target, G-protein coupled receptor GPR37, has been established in house. Assay development is underway using this cell line in order to enable the screening of compounds to identify modulation of the drug target. Discovering tool compounds for the receptor will enable better understanding of the function of GPR37 and hopefully lead to generation of drugs for the treatment of central nervous system disorders. |
| Exploitation Route | Once tool compounds have been identified this will enable validation of GPR37 as a viable drug target for its implicated central nervous system disorders, including Parkinson's disease, autism, bipolar and depressive disorders. This will allow drug discovery schemes to focus on developing drugs which modulate GPR37 for the benefit of pharmaceutical companies, the NHS and the public. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Ongoing research towards the discovery of compounds which have the capacity to treat central nervous system disorders will have a positive economical and societal impact as it will aid the development of drugs for disorders with a clinical unmet need. This will be beneficial to pharmaceutical companies, the NHS and the public. |