Exploring the origins and activation dynamics of the endometriosis-associated macrophage in a novel mouse model
Lead Research Organisation:
University of Edinburgh
Department Name: MRC Centre for Reproductive Health
Abstract
Endometriosis is a chronic inflammatory condition that affects 1 in 10 women of reproductive age. It is associated with debilitating pelvic pain and infertility and has a huge adverse impact on health-related quality of life. Current therapies are limited to surgery or hormonal suppression. Women want new alternatives to current treatment options.
Organisations
People |
ORCID iD |
| Erin Greaves (Primary Supervisor) | |
| Chloe Hogg (Student) |
Publications
Hogg C
(2020)
Endometriosis-Associated Macrophages: Origin, Phenotype, and Function.
in Frontiers in endocrinology
Forster R
(2019)
Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hogg C
(2021)
Macrophages inhibit and enhance endometriosis depending on their origin
in Proceedings of the National Academy of Sciences
Horne AW
(2019)
Repurposing dichloroacetate for the treatment of women with endometriosis.
in Proceedings of the National Academy of Sciences of the United States of America
Chang CY
(2022)
Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications.
in Biomedicines
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/P502030/1 | 01/10/2016 | 30/09/2022 | |||
| 1789503 | Studentship | MR/P502030/1 | 01/09/2016 | 31/08/2019 | Chloe Hogg |
| Description | Barbour Watson Trust- awarded to Chloe Hogg PhD student |
| Amount | £2,000 (GBP) |
| Organisation | University of Edinburgh |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 12/2018 |
| Description | Research Grant |
| Amount | £698,969 (GBP) |
| Funding ID | MR/S002456/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2021 |
| Description | Travel grant |
| Amount | £800 (GBP) |
| Organisation | Society for Reproduction and Fertility |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 07/2018 |
| End | 08/2019 |
| Description | Secretary of the Little France Postgraduate Society |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | On the postgraduate committee I organised a plethora of events from social events to career development workshops. We welcomed new students onto the campus and aided the sometimes difficult transition into postgraduate life. We also set up a SolidariTEA event where postgraduates seeking help could come and get support in a confidential environment, with the aim to promote good mental health and communication between like-minded students facing similar issues. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |