Exploring the origins and activation dynamics of the endometriosis-associated macrophage in a novel mouse model
Lead Research Organisation:
University of Edinburgh
Department Name: MRC Centre for Reproductive Health
Abstract
Endometriosis is a chronic inflammatory condition that affects 1 in 10 women of reproductive age. It is associated with debilitating pelvic pain and infertility and has a huge adverse impact on health-related quality of life. Current therapies are limited to surgery or hormonal suppression. Women want new alternatives to current treatment options.
Organisations
People |
ORCID iD |
Erin Greaves (Primary Supervisor) | |
Chloe Hogg (Student) |
Publications
Horne AW
(2019)
Repurposing dichloroacetate for the treatment of women with endometriosis.
in Proceedings of the National Academy of Sciences of the United States of America
Forster R
(2019)
Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hogg C
(2020)
Endometriosis-Associated Macrophages: Origin, Phenotype, and Function.
in Frontiers in endocrinology
Hogg C
(2021)
Macrophages inhibit and enhance endometriosis depending on their origin.
in Proceedings of the National Academy of Sciences of the United States of America
Chang CY
(2022)
Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications.
in Biomedicines
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/P502030/1 | 01/10/2016 | 30/09/2022 | |||
1789503 | Studentship | MR/P502030/1 | 01/09/2016 | 31/08/2019 | Chloe Hogg |
Description | Barbour Watson Trust- awarded to Chloe Hogg PhD student |
Amount | £2,000 (GBP) |
Organisation | University of Edinburgh |
Sector | Academic/University |
Country | United Kingdom |
Start | 12/2017 |
End | 12/2018 |
Description | Research Grant |
Amount | £698,969 (GBP) |
Funding ID | MR/S002456/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2019 |
End | 12/2021 |
Description | Travel grant |
Amount | £800 (GBP) |
Organisation | Society for Reproduction and Fertility |
Sector | Charity/Non Profit |
Country | Global |
Start | 07/2018 |
End | 08/2019 |
Description | Secretary of the Little France Postgraduate Society |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | On the postgraduate committee I organised a plethora of events from social events to career development workshops. We welcomed new students onto the campus and aided the sometimes difficult transition into postgraduate life. We also set up a SolidariTEA event where postgraduates seeking help could come and get support in a confidential environment, with the aim to promote good mental health and communication between like-minded students facing similar issues. |
Year(s) Of Engagement Activity | 2017,2018,2019 |