Triggered bacteriophage release for the treatment of wound infections
Lead Research Organisation:
University of Bath
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Patenall BL
(2019)
Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition.
in Chemical communications (Cambridge, England)
Wallace L
(2019)
Challenges and Opportunities of pH in Chronic Wounds
in Therapeutic Delivery
Gwynne L
(2019)
Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells.
in Frontiers in chemistry
Williams GT
(2020)
Boronate ester cross-linked PVA hydrogels for the capture and H2O2-mediated release of active fluorophores.
in Chemical communications (Cambridge, England)
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013794/1 | 30/09/2016 | 29/09/2025 | |||
| 1793413 | Studentship | MR/N013794/1 | 30/09/2016 | 30/05/2020 | Lauren Gwynne |
| Description | President's Fund |
| Amount | £1,200 (GBP) |
| Organisation | Society for Applied Microbiology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 06/2019 |
| Description | Siegen |
| Organisation | University of Siegen |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Myself and my research team have developed numerous enzyme-responsive probes to lead to the detection of bacterial infections in wounds. We have also looked into the role in enzymes and their effectiveness as triggers for stimuli-responsive wound dressings. |
| Collaborator Contribution | Researchers at the University of Siegen have taken our probes to incorporate them in different hydrogel systems to get working sensor strips which can be used in clinical settings. |
| Impact | - One publication under review - Three publications currently being written - Development of novel enzyme-responsive fluorescent probes - Development of novel sensor strips - Leading to development of a theranostic device - Multidisciplinary: Organic chemistry, Physical chemistry, Polymer chemistry, Microbiology |
| Start Year | 2018 |
| Description | Reddit Q&A |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Reddit users were able to ask questions to my research group for a period of 2 h related to any aspect of our research and we replied with our thoughts/answers to the question. The main outcome of our involvement in this was to broadcast our research, but to also educate and inform the public on bacterial infections, specifically releated to wound or cathether associated infections, to the best of our knowledge. It was also interesting to see what the general public regarded as important, and what kind of questions they wanted answered, as these were very different compared to clinicians/scientists etc. Overall it was a very rewarding experience |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.reddit.com/r/science/comments/6dgde2/hi_reddit_were_the_biophysical_chemistry_group_at/ |