Examining van der Waals Dispersion Forces between Polarisable Functional Groups
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
The project seeks to understand aromatic stacking interactions that involve molecular contacts between large polarisable groups, and to incorporate their use into molecular machines. The project will use a combination of synthetic chemistry, and a physical organic chemistry approach that compares experimental and computed data to understand the strength of aromatic interactions and their ability to catalyse reactions. The understanding gained will be put into use by covalently modifying transmembrane protein pores with molecular-balance receptors capable of binding substrates and catalysing reactions via stacking interactions as they are translocated across the membrane. The key techniques employed will be organic synthesis, NMR spectroscopy, DFT and energy partitioning methods, bioconjugation reactions.
Organisations
People |
ORCID iD |
Scott Cockroft (Primary Supervisor) | |
Alexander Elmi (Student) |
Publications
Dominelli-Whiteley N
(2017)
Strong Short-Range Cooperativity in Hydrogen-Bond Chains
in Angewandte Chemie International Edition
Haugland MM
(2019)
Synthetically Diversified Protein Nanopores: Resolving Click Reaction Mechanisms.
in ACS nano
Wang D
(2018)
An RNA-dependent mechanism for transient expression of bacterial translocation filaments.
in Nucleic acids research
Zheng Q
(2019)
The Energetic Significance of Metallophilic Interactions.
in Angewandte Chemie (International ed. in English)
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N509644/1 | 01/10/2016 | 30/09/2021 | |||
1796296 | Studentship | EP/N509644/1 | 01/09/2016 | 31/08/2020 | Alexander Elmi |