Investigation of the Plasmodium falciparum RH5-Interacting Protein (RIPR) as a blood-stage malaria vaccine target
Lead Research Organisation:
UNIVERSITY OF OXFORD
Department Name: Clinical Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Alanine DGW
(2019)
Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
in Cell
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013468/1 | 30/09/2016 | 29/09/2025 | |||
| 1808501 | Studentship | MR/N013468/1 | 30/09/2016 | 30/03/2021 | Barnabas Williams |
| Description | Anti-RH5/CyRPA/Ripr mAb and neutralizing epitope identification |
| Amount | $461,957 (USD) |
| Funding ID | INV-030873 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 07/2022 |
| End | 08/2023 |
| Title | R78C - A new malaria vaccine candidate |
| Description | A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of the Blood-stage Malaria Candidate Vaccines RH5.1 in Matrix-M and R78C in Matrix-M in Healthy UK Adults currently ongoing in the UK due to finish in 2024. Mainly funded by OptiMalVax (an EU horizon programme) however R78C was developed as part of my DPhil thesis under this award. |
| Type | Therapeutic Intervention - Vaccines |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2023 |
| Development Status | Actively seeking support |
| Clinical Trial? | Yes |
| UKCRN/ISCTN Identifier | NCT05385471 |
| Impact | Still under initial clinical investigation. |
| Description | Old road campus research building open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Took part in the Jenner institutes stand displaying our work on vaccines for infectious disease. The public could play some games designed to teach them about antibodies and vaccination. |
| Year(s) Of Engagement Activity | 2019 |