Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.
This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.
This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.
People |
ORCID iD |
Peter O'Connor (Primary Supervisor) | |
Tomos Morgan (Student) |
Publications
Floris F
(2017)
Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin
in Journal of the American Society for Mass Spectrometry
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Morgan TE
(2018)
Coupling Electron Capture Dissociation and the Modified Kendrick Mass Defect for Sequencing of a Poly(2-ethyl-2-oxazoline) Polymer.
in Analytical chemistry
Lam YPY
(2018)
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
in Chemical communications (Cambridge, England)
Van Agthoven MA
(2018)
Can Two-Dimensional IR-ECD Mass Spectrometry Improve Peptide de Novo Sequencing?
in Analytical chemistry
Lermyte F
(2019)
MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics.
in Analytical chemistry
Lermyte F
(2019)
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.
in Cells
Lermyte F
(2019)
Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Van Agthoven MA
(2019)
Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry.
in European biophysics journal : EBJ
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/P510695/1 | 01/10/2016 | 31/12/2021 | |||
1837376 | Studentship | EP/P510695/1 | 01/10/2016 | 30/03/2020 | Tomos Morgan |