Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.
This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.
This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.
People |
ORCID iD |
| Peter O'Connor (Primary Supervisor) | |
| Tomos Morgan (Student) |
Publications
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Chiu C
(2020)
Metallocomplex-Peptide Interactions Studied by Ultrahigh Resolution Mass Spectrometry
in Journal of the American Society for Mass Spectrometry
Floris F
(2017)
Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin
in Journal of the American Society for Mass Spectrometry
Lam Y
(2020)
Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?
in Chemical Communications
Lam YPY
(2020)
Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Lam YPY
(2018)
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
in Chemical communications (Cambridge, England)
Lermyte F
(2019)
MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics.
in Analytical chemistry
Lermyte F
(2019)
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.
in Cells
Lermyte F
(2019)
Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Lermyte F
(2019)
Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches.
in Journal of the American Society for Mass Spectrometry
Marzullo BP
(2020)
Advantages of Two-Dimensional Electron-Induced Dissociation and Infrared Multiphoton Dissociation Mass Spectrometry for the Analysis of Agrochemicals.
in Analytical chemistry
Marzullo BP
(2020)
Comparison of Fragmentation Techniques for the Structural Characterization of Singly Charged Agrochemicals.
in Analytical chemistry
Morgan TE
(2020)
Electron Capture Dissociation of Trithiocarbonate-Terminated Acrylamide Homo- and Copolymers: A Terminus-Directed Mechanism?
in Analytical chemistry
Morgan TE
(2018)
Coupling Electron Capture Dissociation and the Modified Kendrick Mass Defect for Sequencing of a Poly(2-ethyl-2-oxazoline) Polymer.
in Analytical chemistry
Paris J
(2020)
Facile Determination of Phosphorylation Sites in Peptides Using Two-Dimensional Mass Spectrometry.
in Analytical chemistry
Van Agthoven MA
(2019)
Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry.
in European biophysics journal : EBJ
Van Agthoven MA
(2019)
Phase relationships in two-dimensional mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Van Agthoven MA
(2018)
Can Two-Dimensional IR-ECD Mass Spectrometry Improve Peptide de Novo Sequencing?
in Analytical chemistry
Wootton C
(2019)
Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation
in The Analyst
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/P510695/1 | 01/10/2016 | 31/12/2021 | |||
| 1837376 | Studentship | EP/P510695/1 | 01/10/2016 | 30/03/2020 | Tomos Morgan |