Proton-sensing GPCR signalling in inflammation
Lead Research Organisation:
University of Cambridge
Department Name: Pharmacology
Abstract
Theme: Bioscience for Health
My project involves the use of cell lines, primary cultured sensory neurones and mice to assess the contributions of proton-sensing G protein-couple receptors in inflammation and the associated pain.
My project involves the use of cell lines, primary cultured sensory neurones and mice to assess the contributions of proton-sensing G protein-couple receptors in inflammation and the associated pain.
Publications
Bohic M
(2023)
Mapping the neuroethological signatures of pain, analgesia, and recovery in mice.
in Neuron
Callejo G
(2020)
In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.
in Biochemical pharmacology
Chakrabarti S
(2018)
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
in Neuropharmacology
Lu VB
(2019)
Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
in Nature communications
Pattison L
(2021)
Proton-sensing G protein-coupled receptor signalling in inflammation
Pattison L
(2021)
Proton-sensing G protein-coupled receptor signalling in inflammation
Pattison L
(2019)
Evolution of acid nociception: ion channels and receptors for detecting acid
in Philosophical Transactions of the Royal Society B: Biological Sciences