Clinical Neuroanatomy - Experimental model for immunotherapy for synucleinopathies
Lead Research Organisation:
University of Southampton
Department Name: Clinical and Experimental Sciences
Abstract
Skills Priority Alignment: Whole Organism
This project will test the hypothesis that novel vaccines designed and synthesised by United Neuroscience (UNS) for neurodegenerative diseases do not create immune complexes in the brain and do not interfere with the clearance of fluid from the brain. As a first step, the student is using the antibodies provided by UNS to test their specificity on human postmortem brains. She will then immunise mice with the same antibodies and inject the proteins (that the antibodies have been raised against) into the brains. After various time points dictated by previous studies in our group, the student will analyse the presence of the immune complexes and associated inflammation. The next step will be to test the effects upon the clearance of solutes form the brains.
This project will test the hypothesis that novel vaccines designed and synthesised by United Neuroscience (UNS) for neurodegenerative diseases do not create immune complexes in the brain and do not interfere with the clearance of fluid from the brain. As a first step, the student is using the antibodies provided by UNS to test their specificity on human postmortem brains. She will then immunise mice with the same antibodies and inject the proteins (that the antibodies have been raised against) into the brains. After various time points dictated by previous studies in our group, the student will analyse the presence of the immune complexes and associated inflammation. The next step will be to test the effects upon the clearance of solutes form the brains.
People |
ORCID iD |
Roxana Carare (Primary Supervisor) | |
Jacqui Nimmo (Student) |
Publications
Nimmo JT
(2022)
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric a-synuclein accumulation in the brain and gut.
in Acta neuropathologica
Nimmo JT
(2020)
Novel antibodies detect additional a-synuclein pathology in synucleinopathies: potential development for immunotherapy.
in Alzheimer's research & therapy
Nimmo, J
(2020)
Peri-arterial pathways for clearance of a-Synuclein and tau from the brain: Implications for the pathogenesis of dementias and for immunotherapy
in Alzheimers Dementia
Nimmo JT
(2021)
Amyloid-ß and a-Synuclein Immunotherapy: From Experimental Studies to Clinical Trials.
in Frontiers in neuroscience
Jacqui Taryn Nimmo
(2021)
Immunotherapy in Synucleinopathies
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/R502261/1 | 01/10/2017 | 30/09/2022 | |||
1949160 | Studentship | MR/R502261/1 | 01/10/2017 | 30/09/2021 | Jacqui Nimmo |