Dynamic Rapid Extraction and Manufacture of Pharmaceuticals (DREAM-Pharma)
Lead Research Organisation:
Brunel University London
Department Name: Institute for Bioengineering
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
It is becoming increasingly important for industries to shorten the time taken to develop manufacturing process for new products, increase efficiency, reduce costs and reduce solvent usage. The Brunel Institute for Bioengineering (BIB) has developed a range of rapid, continuous multistage liquid-liquid extraction centrifuges (known as Dynamic Extraction or DE centrifuges) which use the same principle of purification at all scales. These provide scaleup from analytical to pilot scale capable of processing up to 10kg per day of crude extract with total sample recovery. The prospect of full process (manufacturing) scale dynamic extraction is currently being researched with BBSRC support. This proposal addresses one important part of getting a new advanced Bioprocessing Centre (ABC) operational: the equipping and upgrading of the large scale dynamic extraction centrifuges in the Hazard¿s Laboratory. BIB has a balanced portfolio of research into the scale-up and manufacture of biopharmaceuticals. It is pioneering new research with BBSRC support on the purification of viable biologics using aqueous phase systems, and is consolidating research on the application of dynamic extraction technology to the rapid scale up and manufacture of new pharmaceutical products at trial grades and quantities. It is now in the process of establishing this new Advanced Bioprocessing Centre to act as a platform for the growth of new research on the technology both in scale-up and application as well as stimulating the new initiatives that will inevitably lead on from the proposed research.
People |
ORCID iD |
Ian Sutherland (Principal Investigator) | |
Ian Garrard (Co-Investigator) |
Publications
Chen L
(2007)
Erratum to: "Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography" [J. Chromatogr. A 1142 (2007) 115-122]
in Journal of Chromatography A
Chen L
(2007)
Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography.
in Journal of chromatography. A
DeAmicis C
(2011)
Comparison of preparative reversed phase liquid chromatography and countercurrent chromatography for the kilogram scale purification of crude spinetoram insecticide.
in Journal of chromatography. A
Sutherland I
(2009)
New 18-l process-scale counter-current chromatography centrifuge.
in Journal of chromatography. A
Sutherland I
(2009)
Scale-up of counter-current chromatography: demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale.
in Journal of chromatography. A
Sutherland I
(2011)
Scalable Technology for the Extraction of Pharmaceutics (STEP): the transition from academic knowhow to industrial reality.
in Journal of chromatography. A
Sutherland IA
(2007)
Recent progress on the industrial scale-up of counter-current chromatography.
in Journal of chromatography. A
Wood P
(2007)
Counter-current chromatography separation scaled up from an analytical column to a production column.
in Journal of chromatography. A