Development of perfused multiple micro-bioreactors (TissueFlux.TM)

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We plan to carry out technical development work on the patented technology - perfused multiple microbioreactor systems to speed up its transfer to the commercial sector. Based on the concept developed and proved by a BBSRC project, we will develop necessary accessories including culture medium distributors and connectors and techniques for the surface treatment to the microbioreactors. We will also optimise the shape (according to the size) and size of the microbioreactors using CFD simulations to provide uniform hydrodynamic shear in the test section which is important for the study of cell and stem cell functions. The developed system can perform parallel and semi-high throughput experimentation for drug and toxicity testing with much improved reliability and reproducibility and can reduce the use of animals using 3D model tissue culture. During the project we will continue market research and prepare a business plan for the spin-off company.