Nottingham Arabidopsis Stock Centre (NASC) IV: provision of key Arabidopsis genetic resources for the research community
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Biosciences
Abstract
The Nottingham Arabidopsis Stock Centre (NASC) has provided seed, DNA and information resources to the plant research community for fifteen years. NASC proactively seeks out and absorbs key Arabidopsis genetic resources from the many tens of thousands of new seed stocks and other materials generated every year from laboratories worldwide. We provide a safe depository/repository for these materials and strive to ensure a cost-effective and rapid bulking and distribution of these materials to the wider plant research community. The coming five years will see a substantial enlargement of the stocks held in the centre but will also become a period of consolidation as the focus of the centre moves towards a more intensively characterised and predominantly fixed/inbred collection. this will require increasingly sophisticated material and data management and some development in physical tracking of materials.
Technical Summary
The project will build on the last fifteen years of success for the Nottingham Arabidopsis Stock Centre in the provision of seed, DNA and information resources to the research community. NASC will continue with an appropriate community responsive acquisition policy for key Arabidopsis genetic resources; provide a safe depository for these materials; and will strive to ensure a cost-effective and rapid bulking and distribution of these materials to the wider plant research community. Although this will necessitate further development of the existing resource base in-line with the ongoing generation of resources from the communitgy, our economies of scale and efficient organisation will allow us to manage this expansion. The coming five years will also become a period of consolidation as the focus of the centre moves towards a more intensively characterised and predominantly fixed/inbred collection. This will require increasingly sophisticated material and data management and some development in physical tracking of materials.
Organisations
People |
ORCID iD |
| Sean May (Principal Investigator) |
Publications
Al-Asadi MG
(2017)
A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells.
in Oncotarget
Al-Sandaqchi AT
(2018)
Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using µ-XRF imaging and inductively coupled plasma mass spectrometry.
in Metallomics : integrated biometal science
Baker C
(2007)
Effects of Alzheimer's peptide and alpha1-antichymotrypsin on astrocyte gene expression.
in Neurobiology of aging
Bodi Z
(2012)
Adenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental Defects.
in Frontiers in plant science
Bonthala VS
(2016)
Identification of Gene Modules Associated with Low Temperatures Response in Bambara Groundnut by Network-Based Analysis.
in PloS one
Broadley MR
(2008)
Evidence of neutral transcriptome evolution in plants.
in The New phytologist
Carelli M
(2011)
Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins.
in The Plant cell
| Description | There are more than 22,000 Arabidopsis researchers in >9,000 laboratories worldwide. The Nottingham Arabidopsis Stock Centre (NASC) has a vital core role as infrastructure support for this highly distributed and prolific Arabidopsis community. We provide materials, data and guidance worldwide (> 100,000 seed tubes per annum 2015- 2019); and our existence helps tens of thousands of users to save time, money and effort through centralised services. Our outreach is extensive, regular and user- oriented and we constantly strive to improve both our customer service and our value for the community. |
| Exploitation Route | Our services are equally available to Universities, institutes, companies and international users through simple, intuitive interfaces. Distribution abroad requires the same infrastructure as a purely UK resource but adds value by encouraging international donation of stocks and data, supplementing grant income and helping to consolidate the Arabidopsis and wider plant Community. All European plant research groups requiring Arabidopsis stocks are obliged to use NASC but thousands of non- Europeans access our resource. |
| Sectors | Agriculture, Food and Drink,Energy,Environment,Manufacturing, including Industrial Biotechology,Other |
| URL | http://arabidopsis.info |
| Description | The increasing demands of a growing, prosperous world for improved agricultural products including food, fibre and fuel, intensifies the need for an extensive understanding of the basic biology and ecology of plants. Arabidopsis is the most widely used model system to study plant biology and has delivered numerous breakthroughs in understanding of plant and basic biological processes. The knowledge gained from studies in Arabidopsis serves to advance our understanding of other plant species, particularly crop species, and thus translates into new or improved plant products and increased agricultural productivity. Arabidopsis has underpinned the genomic revolution in plant science and represents the template on which other plant and crop genomes are annotated and assessed. Arabidopsis data is key to modern crop science and through that to food security and quality of life. We are the European Arabidopsis Stock Centre and send out ~100,000+ tubes of seed worldwide per annum. Any one of those tubes can enable or inform a project that may result in any of these impacts. Together with the US stock centre we support the world Arabidopsis community and our impact is through them. |
| Sector | Agriculture, Food and Drink,Energy,Environment,Manufacturing, including Industrial Biotechology,Other |
| Impact Types | Economic |
| Description | BBSRC BBRF |
| Amount | £1,092,256 (GBP) |
| Funding ID | BB/P024068/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2021 |
| Description | The Nottingham Arabidopsis Stock Centre (arabidopsis.info) |
| Amount | £1,485,289 (GBP) |
| Funding ID | BB/V018337/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2021 |
| End | 10/2026 |
| Title | EURISCO |
| Description | EURISCO is a search catalogue providing information about ex situ plant collections maintained in Europe. It is based on a European network of ex situ National Inventories. Since 2014, EURISCO is hosted at and maintained by the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK, Gatersleben, Germany) on behalf of ECPGR. ECPGR and other Central Crop Databases have been established through the initiative of individual institutes and of ECPGR Working Groups. The databases hold passport data and, to varying degrees, characterization and primary evaluation data of the major collections of the respective crops in Europe. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | We have shown commitment to a European wide catalogue of germplasm resources. This was brokered via the UKPGRG group and assisted by DEFRA. Our inclusion of more than 600,000 stocks makes a very strong statement about the relative support of the UK government to germplasm resources compared to our European neighbours. |
| URL | http://www.ecpgr.cgiar.org/resources/latest-news/news-detail/accessions-from-the-nottingham-arabidop... |
| Title | arabidopsis.info |
| Description | The NASC germplasm database holds data on just under 1 million stocks that have been acquired since the centre began in 1990/91. We replaced the Arabidopsis Information Service in Germany (1964 - 1987) and acquired all 200+ stocks from them. In 1999 this was increased to 20,000 and in 2013 passed the 800,000 mark. We hold genomic, genetic, phenotypic, passport, collection, images, and other sundry data about these stocks and make this information freely available to researchers and collaborators worldwide. As part of the database we run a cost-recovery catalogue for ordering stocks which includes user data and a fully developed e-commerce solution bespoke to NASC. We also integrate our data with exteral and internal databases using a variety of mathods from direct data exchange through dynamic URLs to fully fledged Web Services (SOAP and REST). |
| Type Of Material | Database/Collection of data |
| Provided To Others? | Yes |
| Impact | This database underpins the distribution of arabidopsis germplasm resources to the UK and European plant community. It also provides the same service to worldwide users in collaboration/complementarity with the US stock center ABRC. This has accelerated the ease of uptake of germplasm and data associated with these germplasm entities and supported arabidopsis and other plant research to make it one of the most productive model species. |
| URL | http://arabidopsis.info |