Enhanced detection and characterisation of emergent influenza A viruses and avian paramyxoviruses (APMV/NDV): An Anglo-Chinese exchange
Lead Research Organisation:
Animal and Plant Health Agency
Department Name: Statutory and Exotic Viral Diseases
Abstract
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People |
ORCID iD |
| Ian Brown (Principal Investigator) |
Publications
| Description | Significant antigenic diversity in animal H9 influenza virus |
| Exploitation Route | First global maps informing vaccine strain selection for H9 addressing pandemic threat |
| Sectors | Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology |
| Description | Data presented to WHO vaccine strain selection group in Geneva |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | International influence and advice |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Continuous provision of advice to international governments and agencies (ie OIE,FAO,WHO) concerned with disease control. This will include a range of science topics including surveillance type and design, disease infection characteristics for spread, international threat awareness and mitigations, use of tools to effective contain disease, environmental threats from pathogen, informing human health colleagues on zoonotic risk, utility of diagnostics, control tools applicable. All data feds into effective policy making to limit cost to society, reduce burden on government and rural economy, informing the public on threat (including through EFSA and ECDC in Europe); improvements to disease control policy to respond to changes in the epidemiology of the disease. |
| Title | Antigenic catrography for H9 influenza |
| Description | Mapping antigenic epitopes in 3 D visualisation and displaying distance relationships |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | used to inform vaccine strain selection for humans |
| Description | AI INFECTION DYNAMICS |
| Organisation | The Pirbright Institute |
| Department | Avian viral Diseases |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Access to international data on disease not in the public domain Provision of specialist biologicals including virus strains Contributing deep expertise on the pathogen and host infection outcomes together with context for research in a global setting Conducting animal studies to ACDP3/SAPO4: study design and execution with downstream data collection and analyses Preparation of manuscripts and other outputs for communication of the science |
| Collaborator Contribution | Access to surveillance in Central Asia Provision of high volume gene sequencing Data analyses and preparing data for publication Study design in consultation |
| Impact | Yes Virology, Epidemiology and Animal Science 132. Iqbal, M., Essen, S.C., Xiao, H., Brookes, S.M., Brown, I.H., and McCauley J.W. (2012) : Effect of different glycosylation patterns of the haemagglutinin glycoprotein of H7N1 avian influenza viruses on virus replication and transmission in chickens and turkeys. Influenza2012, One Influenza, One World, 11 - 13 September 2012, St. Hilda's College, Oxford, UK. Page 20. |
| Start Year | 2013 |
| Description | International outreach |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | OFFLU (OIE/FAO) international network of institutes providing global expertise on AI (http://www.offlu.net ) |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018 |
| Description | International symposia on AI |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ian Brown co-chaired this major international event presenting the latest science on AI |
| Year(s) Of Engagement Activity | 2012,2015,2018 |
| URL | http://www.flu-lab-net.eu |
| Description | Poultry industry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Provision of science evidence from AI research to stakeholder groups in the UK poultry industry. Data used by industry to make business decisions related to AI threat |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014,2015,2016,2017,2018 |
| Description | Uk research fora |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | wide range of fora where UK researchers formally come together via events/meetings to exchange scientific research knowledge |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018 |