Dynamic mathematical modelling of diversification of transcriptional regulatory networks underlying the genetic variation of E.coli species
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Biosciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Dov Stekel (Principal Investigator) |
Publications
Chumsakul O
(2013)
High-resolution mapping of in vivo genomic transcription factor binding sites using in situ DNase I footprinting and ChIP-seq.
in DNA research : an international journal for rapid publication of reports on genes and genomes
Oshima, T, Ishikawa, S, Onuma, C, Nakamura, K
(2014)
Standard protocols on Next Generation Sequencing (in Japanese)
Takahashi H
(2015)
The dynamic balance of import and export of zinc in Escherichia coli suggests a heterogeneous population response to stress.
in Journal of the Royal Society, Interface
| Description | This research has been jointly conducted between laboratories in the UK and Japan. Our main findings are about the way in which E. coli cells regulate the amount of zinc that they contain. Most importantly, we have found our data can only be explained if we predict that identical cells produce different amounts of the protein that removes zinc from cells. This means that some cells can remove zinc quickly, while others cannot. So if cells move from low to high zinc, some cells will survive, and others will not. |
| Exploitation Route | Zinc is used as an antimicrobial, especially in agriculture, e.g. as footbaths for cattle. We will be interested in applying for further funding to explore the impact of antimiocrobial zinc on microbial populations in agriculture. |
| Sectors | Agriculture, Food and Drink,Environment,Healthcare,Pharmaceuticals and Medical Biotechnology |
| URL | http://rsif.royalsocietypublishing.org/content/12/106/20150069 |
| Description | Collaborative research visits from UK to Japan and Japan to UK |
| Organisation | Nara Institute of Science and Technology |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | The main aim of this grant is to engage in collaborative research between the University of Nottingham and the Nara Institute of Science and Technology and the University of Osaka. Collaborative research visits have been our major activity and several more research visits are planned. I have listed all research visits to date as this single outcome. |
| Start Year | 2010 |
| Description | Talk at MBE 2013, Leicester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk at Modelling Biological Evolution led to stimulating discussion with many delegates. Awareness of research and its approaches |
| Year(s) Of Engagement Activity | 2013 |