Improved adenoviral gene therapy vectors via combined genetic modification of the adenovirus capsid to ablate interaction with blood coagulation facto
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
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Organisations
Publications
Coughlan L
(2014)
Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation.
in Human gene therapy
Duffy MR
(2018)
Generation and characterization of a novel candidate gene therapy and vaccination vector based on human species D adenovirus type 56.
in The Journal of general virology
Lopez-Gordo E
(2014)
The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.
in Expert opinion on drug delivery
Lopez-Gordo E
(2017)
Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum.
in Journal of virology
Robertson S
(2016)
Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop.
in The Journal of general virology
| Description | We showed that there are regions in the adenovirus hexon that are optimal for peptide insertion for retargeting the virus |
| Exploitation Route | For targeted gene delivery using adenovirus vectors for gene therapy |
| Sectors | Pharmaceuticals and Medical Biotechnology |