Develop new methods for functional annotation and downstream analysis of genetic interaction signals
Lead Research Organisation:
University of Edinburgh
Department Name: Centre for Molecular Medicine
Abstract
United States
People |
ORCID iD |
| Wenhua Wei (Principal Investigator) |
Publications
Wei WH
(2014)
Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid.
in Human molecular genetics
Wei WH
(2016)
Immunochip Analyses of Epistasis in Rheumatoid Arthritis Confirm Multiple Interactions within MHC and Suggest Novel Non-MHC Epistatic Signals.
in The Journal of rheumatology
| Description | Interactions between neighbouring markers are useful indicators of regulatory mechanisms underlying complex traits. |
| Exploitation Route | Further studies of additional complex traits following the protocol developed. To develop a new grant bridging statistical and functional interactions |
| Sectors | Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology |
| Description | Not yet. I am profiling local interactions in a disease traits and will try to develop a new proposal based on this idea to bridge statistical and functional interactions |