Structure/function Studies of Vitamin K Epoxide Reductase Isoforms
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
Japan
People |
ORCID iD |
| Neil Bulleid (Principal Investigator) |
Publications
Cao Z
(2016)
The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme.
in The Biochemical journal
Chalmers F
(2017)
Inhibition of IRE1a-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response
in Wellcome Open Research
Chalmers F
(2017)
Inhibition of IRE1a-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response.
in Wellcome open research
Oka OB
(2019)
ERp18 regulates activation of ATF6a during unfolded protein response.
in The EMBO journal
Robinson PJ
(2020)
Protein secondary structure determines the temporal relationship between folding and disulfide formation.
in The Journal of biological chemistry
Robinson PJ
(2017)
Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation.
in The Journal of biological chemistry
| Description | The grant funded a visit to Professor Inaba's laboratory in Japan. As a result we have since obtained funding from the Royal Society for International Exchanges between our labs. |
| Exploitation Route | This award was for a single visit. It did not fund any laboratory work. |
| Sectors | Other |
| Description | Structure function studies on Vitamin K epoxide reductase |
| Organisation | Tohoku University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | The collaboration was between myself and Prtofessor Inaba at Tohoku University in Sendai. It was supported by a BBSRC and Royal Society International Exchange grants. We prvided training for members of tyhe Inaba lab in Glasgow and evaluated the topology of VKOR and evaluated its interaction with members of the PDI family of ER proteins. |
| Collaborator Contribution | Provided training in structural biology to members of my group as well as intellectual input into the research project centred around VKOR. |
| Impact | Cao Z., van Lith, M., Mitchell, L.J., Pringle, M.A., Inaba, K., Bulleid N.J. (2016) The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme. Biochem J., 473, 851-8 |
| Start Year | 2014 |