Combining stem cell science and tissue engineering to study the development and repair of human skeletal tissues - Osteochondral mechanobiology
Lead Research Organisation:
Keele University
Department Name: Inst for Science and Tech in Medicine
Abstract
United States
Publications
Chapman V
(2017)
Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis.
in Stem cells international
El Haj A. J.
(2016)
Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment
in TISSUE ENGINEERING PART A
Henstock JR
(2018)
Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells.
in Journal of tissue engineering
Markides H
(2018)
Translation of remote control regenerative technologies for bone repair.
in NPJ Regenerative medicine
Markides H
(2015)
Overcoming translational challenges - The delivery of mechanical stimuli in vivo
in The International Journal of Biochemistry & Cell Biology
| Description | This award funded a knowledge and technology transfer from Columbia University (NYC) to a UK Universities (Keele). The award covered research into an emerging US research area (Mechano-medicine) and has therefore increased the UK capacity for research in tissue engineering and mechanotransduction, and widened the availability of human tissue models for musculoskeletal disease, chiefly diabetes-associated arthritis. A paper based on the work pump-primed by the ITAS (ISIS) award is currently in preparation between the original PI / BBSRC grant-holder, the ITAS secondment lead in the USA and the PDRA, who now holds an independent research fellowship at the University of Liverpool. The receipt of the ITAS (ISIS) award was instrumental in future capacity building by enabling researcher career development. The PDRA who conducted the research visit from Keele has become established as an independent academic ( Liverpool University Tenure Track Fellowship scheme) as a result of the ITAS scheme, which has enabled further narrative impact through his engagement with the Widening Participation in undergraduate recruitment agenda, STEM ambassadors programme and further narrative impact via the University of Liverpool's public/societal engagement programme and Business Gateway. A joint paper is currently in preparation. Following the ITAS award the PDRA has been invited to give the following talks featuring work conducted as part of the scheme: ? Invited keynote at the World Congress of Biomechanics, Dublin (July 2018) ? Invited speaker at FIRM (Spain) and career development panellist (2016) ? Invited talk at University of Manchester Regenerative Medicine Network (October 2016) The ITAS experience also provided experience that indirectly facilitated his appointment to the following positions: ? Invited to RCUK expert review panel for updating the concordat for researcher development (2017) ? UoL ECR group chair and representative to the University Research Strategy Group (2017-18) ? UoL ECR & Returners fund grant review committee and introducing member (2017) ? Royal Society Parliamentary Pairing Scheme 2015 participant(2015) |
| Exploitation Route | The PDRA has been highly active in the BBSRC Skills & Careers postdoctoral development panel, and attended meetings with the Royal Society of Biology as part of their policy for engaging with PDRAs and their career development. He was recently appointed to the expert review panel for the current RCUK review of the concordat to support researcher (PDRA) development. He has been particularly supportive of the important role that international collaborative opportunities such as this play in supporting skills and careers development for PDRAs. |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | The ITAS (ISIS) award funded PDRA travel and subsistence in the USA for 3 months. Over this time a human tissue engineered cartilage model was learned, developed and expanded into multiple new research directions for tissue engineering and disease modelling. The key impacts are in personnel development as the PDRA now has achieved a University tenure-track fellowship (University of Liverpool) and is applying for independent grants to continue this work. Further impact arises from the model itself, which enables new research into both tissue engineered cartilage and acts as a cartilage disease model. The PDRA has engaged with musculoskeletal patient involvement groups and used to model as a tool to explain cartilage health in ageing. The PDRA has also been highly active in promoting the value of the ITAS scheme through his previous role in the BBSRC Skills & Careers postdoctoral development panel, and the current RCUK review of the concordat to support researcher (PDRA) development.The ITAS funding was essential to the PDRA career development and progression. As a result, the following successful funding applications (which all feature the models or techniques learned during the ITAS) have been awarded: 2017 University of Georgia, USA - pump-priming award (£1,000) 2017 Wellcome Trust summer scholarship (£2,000 undergraduate student stipend for 8 weeks) 2016 Royal Society equipment grant - bioreactor purchase (£15,000) 2016 Institute-funded PhD studentship (consumables £21,000) 2015 Wellcome Trust fellowship (£20,000) |
| First Year Of Impact | 2016 |
| Sector | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal,Economic |
| Description | MRc UKRMP Aceleular Delivery Hub |
| Amount | £750,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 04/2018 |
| Description | School Visit (Uttoxeter) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 100 A Level students attended a career and scientific research awareness lecture at Denstone College. Subsequently, I have had contacts from students interested in information on further follow up research activities. |
| Year(s) Of Engagement Activity | 2020 |