Taiwan Partnering Award for the Analysis of Digitised Images of Immunohistochemically (IHC) Stained Serial Tissue Sections of Mouse Pancreata
Lead Research Organisation:
University of Warwick
Department Name: School of Life Sciences
Abstract
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| Description | At the Warwick end, we have developed a software for registration of whole-slide stained images of serial sections through mouse pancreas. This software will be used in our further research analysing the data collected during the course of this project which includes of reconstruction of 3D structure of microscopic objects and regions of interests (e.g., cells and micro-vasculature), an important task in the emerging area of digital pathology. |
| Exploitation Route | Ph.D. students in Warwick's computer science department are continuing to work on various interesting problems relating to registration of whole-slide stained images of serial sections through mouse pancreas- building 3D-images is only one application. For example, this gives another approach to multiple co-location of proteins. One uses different IHC stains for different proteins on a series of adjacent sections. If the sections are thin enough, an accurate registration will find cells that are cut in half, with one half in one section and the other half in the other section. Often cells of the same type occur in clusters, so, even if the cells are not cut in half, you can get still estimate the extent of co-location of different proteins. Reconstruction of 3D structures within tissues (e.g., cells and micro-vasculature) is an important area of digital pathology, and our results will provide an ideal platform for launching further joint research projects in both basic science (of diseases such as cancer and diabetes) and personalised healthcare involving detailed microscopic analysis of human and animal histology specimens in future. |
| Sectors | Digital/Communication/Information Technologies (including Software),Pharmaceuticals and Medical Biotechnology |