MAGMA

Lead Research Organisation: University of Oxford
Department Name: Oxford Chemistry

Abstract

NMR is an important tool in drug discovery. Its use is rising in industry owing to its applicability notably to disordered, and membrane proteins that are of significant interest, but are not amenable to crystallography. Widespread use of NMR has been limited by its complexity, and the size of molecules it can be applied to. We have developed MAGMA, a novel analytical approach that facilitates the study of 'large', >30KDa, proteins in structure-function research, applicable to the majority of targets of interest to the biopharmaceutical industry. Our approach relates features in NMR spectra to specific atoms in the molecule, taking a process that could take several labour-intensive months with costly samples down to a single sample and a few hours. To realise the commercial potential, this project will allow us to refine the MAGMA software that can be used by a non-specialist. We seek to license this robust software platform for use in academic research, and commercial drug discovery.

Publications

10 25 50
publication icon
Karunanithy G (2019) INDIANA: An in-cell diffusion method to characterize the size, abundance and permeability of cells. in Journal of magnetic resonance (San Diego, Calif. : 1997)

 
Description Software is now available for analysis of methylTROSY NMR data. We have had tremendous interest from various pharmaceutical companies who have since purchased our software.
Exploitation Route The methods are useful to scientists that analyse NMR data.
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology
 
Description We used this grant to develop software to analyse NMR data for use by pharmaceutical companies, and to build a datapack to help show them how useful this can be.
First Year Of Impact 2018
Sector Chemicals,Manufacturing, including Industrial Biotechology