A new bioimaging tool for profiling intracellular reactions and drug distribution
Lead Research Organisation:
University of Edinburgh
Department Name: Edinburgh Cancer Research Centre
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Lee M
(2021)
Recent advances in the use of stimulated Raman scattering in histopathology.
in The Analyst
Ravindra MP
(2023)
Stretching the Bisalkyne Raman Spectral Palette Reveals a New Electrophilic Covalent Motif.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Sepp K
(2020)
Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells.
in Journal of medicinal chemistry
Steven C
(2022)
Design, Synthesis, and Analytical Evaluation of Fsp 3 -Inspired Raman Probes for Cellular Imaging
in European Journal of Organic Chemistry
Vanden-Hehir S
(2019)
Raman Imaging of Nanocarriers for Drug Delivery.
in Nanomaterials (Basel, Switzerland)
Vanden-Hehir S
(2019)
Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering Microscopy.
in Biomacromolecules
| Description | Consultancy work was carried out and defined the market landscape of our imaging technology. This has identified a number of commercial and academic interactions for follow-up and has heloped focus our current research goals. In addition input into the intellectual property associated with the chemical imaging probes being developed was provided which has guided our further work. |
| Exploitation Route | N/A |
| Sectors | Agriculture Food and Drink Pharmaceuticals and Medical Biotechnology |
| Description | CASE Award |
| Amount | £70,720 (GBP) |
| Organisation | UCB SA |
| Department | UCB Pharma |
| Sector | Private |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 10/2026 |
| Description | Development of Raman probes for live cell tracking |
| Amount | £60,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 08/2020 |
| End | 02/2024 |
| Description | Development of bioorthogonal stimulated Raman scattering microscopy for evaluation of drug biodistribution |
| Amount | £29,500 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 08/2023 |
| Description | Bioimaging Expertise Network - GSK |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Research and Development GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Participation in Bioimaging Expertise Network Symposium May 2019 |
| Collaborator Contribution | Organisation of Bioimaging Expertise Network Symposium May 2019 |
| Impact | Multidisciplinary collaboration involving chemists, biologists and imaging experts |
| Start Year | 2019 |
| Description | Bridging Nordic Microscopy Infrastructure Meeting (Odense) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Meeting to discuss use of coherent raman imaging as a tool to understand biological processes and clinical translational resulting in active debate on methodologies used |
| Year(s) Of Engagement Activity | 2023 |
| Description | Coherent Raman Microscopy Workshop (Exeter) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Workshop for researchers from academia and industry to discuss the use of coherent Raman microscopy as a discovery tool and potential clinical applications |
| Year(s) Of Engagement Activity | 2022 |
| Description | Coherent Raman Scattering conference (Odense) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at the Coherent Raman Scattering (CRS) conference in Odense, Denmark (2-4th Decemeber 2019) to discuss biological and pharmaceutical applications of Coherent Raman scattering microscopy. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.sdu.dk/imaging/-/media/imaging/filer/meetings/2019/crs2019/coherent+raman+scattering+con... |
| Description | Conference chair and presentation SPIE Photonics West (San Francisco) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Speaker and conference chair at SPIE Photonics West conference, San Francisco 28th January - 2nd February 2023. To share recent data and meet researchers in the field. New collaborations instigated. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://spie.org/conferences-and-exhibitions/photonics-west |
| Description | Conference talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at EPSRC CONRAST Coherent Raman workshop, Exeter 12-13 September 2022 to discuss latest advances in the field |
| Year(s) Of Engagement Activity | 2022 |