A new bioimaging tool for profiling intracellular reactions and drug distribution
Lead Research Organisation:
University of Edinburgh
Department Name: Edinburgh Cancer Research Centre
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Lee M
(2021)
Recent advances in the use of stimulated Raman scattering in histopathology.
in The Analyst
Ravindra MP
(2023)
Stretching the Bisalkyne Raman Spectral Palette Reveals a New Electrophilic Covalent Motif.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Sepp K
(2020)
Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells.
in Journal of medicinal chemistry
Steven C
(2022)
Design, Synthesis, and Analytical Evaluation of Fsp 3 -Inspired Raman Probes for Cellular Imaging
in European Journal of Organic Chemistry
Vanden-Hehir S
(2019)
Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering Microscopy.
in Biomacromolecules
Vanden-Hehir S
(2019)
Raman Imaging of Nanocarriers for Drug Delivery.
in Nanomaterials (Basel, Switzerland)
| Description | Consultancy work was carried out and defined the market landscape of our imaging technology. This has identified a number of commercial and academic interactions for follow-up and has heloped focus our current research goals. In addition input into the intellectual property associated with the chemical imaging probes being developed was provided which has guided our further work. |
| Exploitation Route | N/A |
| Sectors | Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology |
| Description | Development of Raman probes for live cell tracking |
| Amount | £60,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 09/2020 |
| End | 02/2024 |
| Description | Development of bioorthogonal stimulated Raman scattering microscopy for evaluation of drug biodistribution |
| Amount | £29,500 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 08/2023 |
| Description | Bioimaging Expertise Network - GSK |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Research and Development GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Participation in Bioimaging Expertise Network Symposium May 2019 |
| Collaborator Contribution | Organisation of Bioimaging Expertise Network Symposium May 2019 |
| Impact | Multidisciplinary collaboration involving chemists, biologists and imaging experts |
| Start Year | 2019 |