Harnessing plant biosynthetic pathways to explore novel chemical space in a class of compounds with significant pharmaceutical potential
Lead Research Organisation:
John Innes Centre
Department Name: Metabolic Biology
Abstract
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Organisations
People |
ORCID iD |
| Anne Osbourn (Principal Investigator) |
| Description | The Pathfinder award was used to research potential targets for drug development. Based on this we have put together a business plan and created a shell company. Discussions with potential investors are currently underway. |
| Exploitation Route | The purpose of the award was to identify potential targets for development for a proposed spin-out company. Once investment has been secured the company will recruit and commence operations. |
| Sectors | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | A new spin-out company has been founded and efforts to secure investment are underway. |
| First Year Of Impact | 2020 |
| Sector | Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Company Name | Hothouse Bioengineering Limited |
| Description | HotHouse is a platform biotechnology company that aims to make DNA-encoded chemical libraries for drug discovery |
| Year Established | 2020 |
| Impact | A shell company has been set up and discussions with potential investors are underway. |
| Description | Biochemistry Focus Webinar Series: Developments in Industrial Biotechnology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Developments in Industrial Biotechnology https://www.youtube.com/watch?v=nj3gNIInKA0&feature=emb_title |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=nj3gNIInKA0&feature=emb_title |
| Description | High-Value Biorenewables Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | High Value Biorenewables Network Meeting 20-21 October 2020 https://www.highvaluebiorenewables.net/events/ |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.highvaluebiorenewables.net/events/ |
| Description | Norwich Science Festival satellite event at Diss Corn Hall |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We took an activity stand to a science discovery day at Diss Corn Hall. This event was set up as a satellite venue for the very popular Norwich Science Festival to try and reach a broader audience. There were 3 workshop sessions throughout the day for 50 children per workshop and their families, all of which were fully booked! We took a stand that focused on the instructions held within DNA to 'make stuff' which was explained by inviting people to engage with our robot DNA Dave, pushing buttons and turning cogs to complete transcription and translation to make new products. We used examples from plants that people would be familiar with such as menthol, limonoids, vanillin and anthocyanins and then invited children to extract anthocyanins from red cabbage to use to make colour-changing paint. Many of the parents were amazed how easy the process was and were keen to build on the experiment at home with their children to make a colour palette of paints using pigments from plants and acids and bases. |
| Year(s) Of Engagement Activity | 2023 |